Sermorelin acetate

Sermorelin acetate is the acetate salt of a 29-amino-acid fragment of human growth hormone releasing hormone. It is produced by solid phase synthesis and supplied as a lyophilised white powder. Purchasing interest is concentrated in 503A facilities preparing single-dose and multi-dose vials for physician office use.

Content and purity vary widely between manufacturers because acetate and water fractions are frequently omitted from the certificate of analysis. Peptide content by nitrogen determination and HPLC purity should both be stated before a lot is compared on price.

Typical related substances are deletion and truncation sequences from incomplete coupling, along with acetylated and oxidised variants; total related substances of 1.5 to 2.5 percent are common.